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NoBites Abroad · Destinations · Zambia · South Luangwa National Park
Quick Briefing · MFU

South Luangwa is malaria country in every month. Its tsetse flies call for thick, neutral sleeves.

Disease risk ElevatedBites Noticeable
  • Travel clinic CDC recommends medicine or vaccines for some areas · which ones
  • No CDC travel notice for mosquito-borne disease
Rated year-roundFull picture ↓

The CDC recommends malaria prevention medicine for all of Zambia, Mfuwe and every camp in the park included. By day, tsetse flies bite on drives and walks, and a few carry sleeping sickness, which is rare among visitors but has been traced to this park more often than to any other in Zambia.

Yes, and the CDC recommends malaria prevention medicine for all of Zambia in every month, so Mfuwe and every camp in South Luangwa are covered. By day, the biter on drives and walks is the tsetse fly. A few carry sleeping sickness, which is rare among visitors but has been traced to this park more often than to any other in Zambia.

Disease risk ElevatedCDC recommends malaria medicine for all of Zambia in every month, and South Luangwa's tsetse can carry sleeping sickness, rare among visitors but linked to 4 traveler cases in 2011–2020.
Bite nuisance NoticeableTsetse by day on drives and walks, patchy and worst in woodland late in the dry season; mosquitoes at the river lodges from dusk.
CirculatingMalaria (all of Zambia)Sleeping sickness (tsetse, rare)Tick-bite fever (walks)No yellow fever vaccine advisedNot on CDC's dengue list
CDC noticesNo country-specific notice for mosquito-borne disease
Travel clinicCDC recommends malaria medicine for all areas of Zambia in every season: atovaquone-proguanil, doxycycline, mefloquine or tafenoquine. Yellow fever vaccine is not recommended for South Luangwa, but proof is required from travelers 1 year or older arriving from a country with yellow fever risk, including layovers of more than 12 hours there. See a travel clinic 4–6 weeks before you fly.
When to goJune–August, cool and dry, tends to be lightest for mosquitoes and, by visitors' accounts, for tsetse. September–October brings prime game viewing, heat and the worst tsetse. The November–April rains bring the most mosquitoes and malaria, and many bush camps close. CDC's advice applies in every month.
Data checkedOctober 2026 · sources

Malaria in every month

What CDC says: "CDC recommends that travelers going to Zambia take prescription medicine to prevent malaria." It gives the transmission areas as "All" and lists "Atovaquone-proguanil, doxycycline, mefloquine, tafenoquine," with no exception for any park or season. What we suggest you do with this: book a travel-medicine appointment 4–6 weeks before departure and bring every camp and your dates. Our malaria-zone checklist covers the rest.

Eastern Province, home to Mfuwe, is high-transmission country. A 2012 national survey called it one of two "malaria hyper-endemic provinces," with PCR finding parasites in 54.3% of 873 children under six across Eastern and Luapula provinces. The CDC's Level 2 Global Polio notice lists Zambia, and adults may get a one-time booster. Our Zambia briefing covers the rest of the country.

Tsetse and sleeping sickness

The CDC lists African sleeping sickness, spread by tsetse, for Zambia, and the Luangwa Valley is a recognized focus of its rhodesiense form. Of 278 tsetse trapped around Mambwe District villages next to the park in 2019–2020, 85.3% were Glossina pallidipes, and 2 flies (0.7%) carried the human-infective parasite.

For visitors it is rare, but real. WHO counted 35 rhodesiense cases diagnosed outside endemic countries in 2011–2020, and 4 were infected in South Luangwa: a tour operator diagnosed in London in 2014 and tourists diagnosed in Baltimore in December 2016, Frankfurt in 2017 and Johannesburg in 2018. Zambia reported 70 cases in all in 2013–2022. WHO's highest-risk Zambian areas in 2018–2022 were small parts of Kafue National Park and the West Petauke area.

Visitors describe the flies as patchy, with a reputation for being worst in thick woodland and building toward October. They bite by day through thin fabric. The CDC says they are drawn to bright and contrasting colors, and visitors add dark blue and black. Wear thick, loose long sleeves and trousers in khaki, olive or tan, treated with permethrin as the CDC advises for clothing.

Evenings by the river

The Mfuwe lodges sit on the Luangwa and its lagoons, and malaria mosquitoes bite from dusk through the night, which covers sundowners, night drives and dinner outdoors. Reapply repellent before the night drive, keep long sleeves on and sleep under the net. Don't swim in the river or the lagoons, where the CDC's schistosomiasis warning applies, and check for ticks after walking safaris, since the CDC lists African tick-bite fever.

When to go

Most camps run from roughly May or June to October, and many bush camps tend to close for the rains. June to August is cool and tends to be lightest for mosquitoes and, by visitors' accounts, for tsetse. September and October are hot, with prime game viewing along the shrinking river and tsetse at their worst. The November–April rains bring the most mosquitoes and malaria.

Where you're going

safari

Mfuwe's riverfront lodges

Disease risk ElevatedBite nuisance Noticeable

Lodges on the Luangwa and its lagoons near the main bridge into the park, with sundowners and night drives in the malaria hours. Reapply repellent before the night drive and keep long sleeves on.

safari

Nsefu Sector

Disease risk ElevatedBite nuisance Noticeable

The east-bank sector north of Mfuwe. Nsefu was among the villages where tsetse were trapped in 2019–2020, when 2 of 278 flies carried the human-infective parasite, so dress for them on drives.

safari

Bush camps & walking safaris

Disease risk ElevatedBite nuisance Annoying

Smaller camps deeper in the park, where walking is the main activity. On foot, thick neutral long sleeves, trousers tucked into socks and a tick check afterward matter most.

countryside

Lupande village visits

Disease risk ElevatedBite nuisance Noticeable

Village and school visits outside the park, in the farming areas where Mambwe District's sleeping sickness research is concentrated. Visits are short and by day, and the same malaria advice applies.

Adding Livingstone? See our Victoria Falls briefing. For Tanzania's tsetse parks, see the Serengeti briefing.

The South Luangwa kit

Treated clothing for the day, repellent for the river evenings.
  • Permethrin 0.5% for safari clothes: treat thick, neutral long sleeves, trousers and socks at home 48 hours before you fly. In a 1989 Zambian vehicle trial, permethrin-treated mesh jackets cut tsetse bites by 75%; the study is old, so take that as a rough guide. It goes on clothing, never on skin.
  • Picaridin 20% travel sprays for exposed skin at sundowners and on night drives. One 3.4 oz bottle covers about a week for one person.

What travelers report

Paraphrased from a TripAdvisor trip report and a camp review and linked so you can read them in full. Both trips are a few years old, and tsetse vary by area and month.

  • Kafue, South Luangwa and Lower Zambezi · October · 2021

    On an October 2021 trip, the poster found tsetse minimal in South Luangwa and the Lower Zambezi but anywhere from terrible to tolerable in Kafue. They were heaviest on the tree-lined road to Busanga Plains, where the bites came on the slower drive back, and rarely a problem on the open plains. Lodges burned elephant dung on drives, which helped without stopping the flies. TripAdvisor ↗

  • Island Bush Camp, South Luangwa · 2019

    The guest did the walking safaris in the mornings because afternoon tsetse could become unpleasant, and found that burning elephant dung on the vehicle did the trick. TripAdvisor ↗

One rule outlasts the trip. Any fever during or after your trip means a doctor visit and a malaria test, and you tell the doctor you were in the Luangwa Valley and ask about sleeping sickness as well as malaria. With malaria in the picture, the rule holds for a full year.

Traveler questions

Do I need malaria pills for South Luangwa?

The CDC recommends malaria prevention medicine for all of Zambia, with no exception for any area or season, so Mfuwe and every camp in the park are covered, the cool June–August months included. It lists atovaquone-proguanil, doxycycline, mefloquine and tafenoquine. Which one fits you is a call for a travel clinic, made 4–6 weeks before departure. Our malaria-zone checklist covers the rest.

How common is sleeping sickness among South Luangwa visitors?

Rare, but real. WHO counted 35 rhodesiense cases diagnosed outside endemic countries in 2011–2020. Thirteen were infected in Zambia and 4 in South Luangwa, among them a tourist diagnosed in Baltimore in December 2016. Zambia reported 70 cases in all in 2013–2022, between 3 and 15 a year. In exported cases, symptoms usually showed up within 1–3 weeks, so a fever or a painful, swollen sore at a bite site in that window means an urgent doctor visit.

Does repellent work on tsetse?

It has a reputation for doing little, though one field trial found it helped. In a 1989 vehicle trial in Zambia, high-strength DEET on exposed skin gave 76–87% protection against tsetse bites, and permethrin-treated mesh jackets cut bites by 75%. Treated coveralls alone did little for uncovered skin. The trial is old, so treat the numbers as a guide, and use treated clothing and repellent on skin together.

Can I swim in the Luangwa?

The CDC says "Schistosomiasis, a parasitic infection that can be spread in fresh water, is found in Zambia" and advises, "Avoid swimming in fresh, unchlorinated water, such as lakes, ponds, or rivers." That rules out the Luangwa and its lagoons.

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